Chapter 7 Endomembrane system, Protein Sorting and membrane trafficking

Content of this chapter

Outline

1. The Compartmentalization in Eukaryotic Cells
         A. Cytosol and Endomembrane System
         B. Endomembrane System
         C. The Dynamic Nature of the Endomembrane System
         D. A few approaches to the study of cytomembranes
2. The structure and functions of Endoplasmic Reticulum(ER)
           A. Functions of the rER .
           B. Functions of the sER
3. The structure and functions of Golgi complex
         A.The polarity of Golgi complex
         B. The Functions of Golgi complex
       
4. The structure and functions of Lysosomes
          A. Characteristics of Lysosomes
          B. The Functions of Lysosomes
          C. Lysosomes and Diseases
          D. Biogenesis of Lysosomes
5. Protein Sorting
         A. Overview of sorting of nuclear-encoded proteins in eukaryotic cells
         B. Signal Hypothesis --G.Blobel & D.Sabatini,1971. A model for the Signal Mechanism of Cotranslational Import
         C. A Model for the Postranslational Import of Polypeptides into the Mit.
6. Types of Vesicle Transport and Their Functions
         A. The three different types of coated vesicles.
         B. The SNARE Hypothesis for Transport Vesicle Targeting and Fusion
         C. Motor proteins mediate movement of vesicles along MT
         D. Maintenance of membrane asymmetry
         E. Membrane flow